mRNA Microlearning
A microsite to explain the fundamentals of mRNA vaccine delivery
A microsite to explain the fundamentals of mRNA vaccine delivery
Role:
Illustration, UX.UI
Tools:
Adobe XD, Illustrator
Date:
January 2023
Publication:
N/A
I was asked to help one of my pharma clients concept a mircosite to explain the basics of mRNA vaccines. We settled on infinite scrolling for the UX and then built out 12 total pages of content for the user to move through in a step-wise fashion. For each content page I created the vector illustrations to accompany the text. Page flows were laid out initially in XD and then handed off to the Development team for programming.
I was asked to help one of my pharma clients concept a mircosite to explain the basics of mRNA vaccines. We settled on infinite scrolling for the UX and then built out 12 total pages of content for the user to move through in a step-wise fashion. For each content page I created the vector illustrations to accompany the text. Page flows were laid out initially in XD and then handed off to the Development team for programming.
R E F E R E N C E S
R E F E R E N C E S
R E F E R E N C E S
R E F E R E N C E S
Pardi, N., Hogan, M. J., Porter, F. W. & Weissman, D. mRNA vaccines — a new era in vaccinology. Nat. Rev. Drug Discov. 17, 261–279 (2018).
Kuehner, J. N., Pearson, E. L. & Moore, C. Unravelling the means to an end: RNA polymerase II transcription termination. Nat. Rev. Mol. Cell Biol. 12, 283–294 (2011).
Abbondanzieri, E. A., Greenleaf, W. J., Shaevitz, J. W., Landick, R. & Block, S. M. Direct observation of base-pair stepping by RNA polymerase. Nature 438, 460–465 (2005).
Patel, A. A. & Steitz, J. A. Splicing double: insights from the second spliceosome. Nat. Rev. Mol. Cell Biol. 4, 960–970 (2003).
Wilusz, C. J., Wormington, M. & Peltz, S. W. The cap-to-tail guide to mRNA turnover. Nat. Rev. Mol. Cell Biol. 2, 237–246 (2001).
Katahira, J. Nuclear Export of Messenger RNA. Genes 6, 163–184 (2015).
Pemberton, L. F. & Paschal, B. M. Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export. Traffic 6, 187–198 (2005).
Bertram, G., Innes, S., Minella, O., Richardson, J. P. & Stansfield, I. Endless possibilities: translation termination and stop codon recognition. Microbiol. Read. Engl. 147, 255–269 (2001).
Cannarozzi, G. et al. A role for codon order in translation dynamics. Cell 141, 355–367 (2010).
RajBhandary, U. L. More surprises in translation: Initiation without the initiator tRNA. Proc. Natl. Acad. Sci. 97, 1325–1327 (2000).
Lareau, L. F., Hite, D. H., Hogan, G. J. & Brown, P. O. Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments. eLife 3, e01257 (2014).
Ramazi, S. & Zahiri, J. Post-translational modifications in proteins: resources, tools and prediction methods. Database 2021, baab012 (2021).
Garneau, N. L., Wilusz, J. & Wilusz, C. J. The highways and byways of mRNA decay. Nat. Rev. Mol. Cell Biol. 8, 113–126 (2007).
Fasullo, M. & Endres, L. Nucleotide Salvage Deficiencies, DNA Damage and Neurodegeneration. Int. J. Mol. Sci. 16, 9431–9449 (2015).
Chaudhary, N., Weissman, D. & Whitehead, K. A. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat. Rev. Drug Discov. 20, 817–838 (2021).
Painter, M. M. et al. Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination. Immunity 54, 2133-2142.e3 (2021).
Marshall, J. S., Warrington, R., Watson, W. & Kim, H. L. An introduction to immunology and immunopathology. Allergy Asthma Clin. Immunol. 14, 49 (2018).
Pollard, A. J. & Bijker, E. M. A guide to vaccinology: from basic principles to new developments. Nat. Rev. Immunol. 21, 83–100 (2021).
Pardi, N., Hogan, M. J., Porter, F. W. & Weissman, D. mRNA vaccines — a new era in vaccinology. Nat. Rev. Drug Discov. 17, 261–279 (2018).
Kuehner, J. N., Pearson, E. L. & Moore, C. Unravelling the means to an end: RNA polymerase II transcription termination. Nat. Rev. Mol. Cell Biol. 12, 283–294 (2011).
Abbondanzieri, E. A., Greenleaf, W. J., Shaevitz, J. W., Landick, R. & Block, S. M. Direct observation of base-pair stepping by RNA polymerase. Nature 438, 460–465 (2005).
Patel, A. A. & Steitz, J. A. Splicing double: insights from the second spliceosome. Nat. Rev. Mol. Cell Biol. 4, 960–970 (2003).
Wilusz, C. J., Wormington, M. & Peltz, S. W. The cap-to-tail guide to mRNA turnover. Nat. Rev. Mol. Cell Biol. 2, 237–246 (2001).
Katahira, J. Nuclear Export of Messenger RNA. Genes 6, 163–184 (2015).
Pemberton, L. F. & Paschal, B. M. Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export. Traffic 6, 187–198 (2005).
Bertram, G., Innes, S., Minella, O., Richardson, J. P. & Stansfield, I. Endless possibilities: translation termination and stop codon recognition. Microbiol. Read. Engl. 147, 255–269 (2001).
Pardi, N., Hogan, M. J., Porter, F. W. & Weissman, D. mRNA vaccines — a new era in vaccinology. Nat. Rev. Drug Discov. 17, 261–279 (2018).
Kuehner, J. N., Pearson, E. L. & Moore, C. Unravelling the means to an end: RNA polymerase II transcription termination. Nat. Rev. Mol. Cell Biol. 12, 283–294 (2011).
Abbondanzieri, E. A., Greenleaf, W. J., Shaevitz, J. W., Landick, R. & Block, S. M. Direct observation of base-pair stepping by RNA polymerase. Nature 438, 460–465 (2005).
Patel, A. A. & Steitz, J. A. Splicing double: insights from the second spliceosome. Nat. Rev. Mol. Cell Biol. 4, 960–970 (2003).
Wilusz, C. J., Wormington, M. & Peltz, S. W. The cap-to-tail guide to mRNA turnover. Nat. Rev. Mol. Cell Biol. 2, 237–246 (2001).
Katahira, J. Nuclear Export of Messenger RNA. Genes 6, 163–184 (2015).
Pemberton, L. F. & Paschal, B. M. Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export. Traffic 6, 187–198 (2005).
Bertram, G., Innes, S., Minella, O., Richardson, J. P. & Stansfield, I. Endless possibilities: translation termination and stop codon recognition. Microbiol. Read. Engl. 147, 255–269 (2001).
Cannarozzi, G. et al. A role for codon order in translation dynamics. Cell 141, 355–367 (2010).
RajBhandary, U. L. More surprises in translation: Initiation without the initiator tRNA. Proc. Natl. Acad. Sci. 97, 1325–1327 (2000).
Lareau, L. F., Hite, D. H., Hogan, G. J. & Brown, P. O. Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments. eLife 3, e01257 (2014).
Ramazi, S. & Zahiri, J. Post-translational modifications in proteins: resources, tools and prediction methods. Database 2021, baab012 (2021).
Garneau, N. L., Wilusz, J. & Wilusz, C. J. The highways and byways of mRNA decay. Nat. Rev. Mol. Cell Biol. 8, 113–126 (2007).
Fasullo, M. & Endres, L. Nucleotide Salvage Deficiencies, DNA Damage and Neurodegeneration. Int. J. Mol. Sci. 16, 9431–9449 (2015).
Chaudhary, N., Weissman, D. & Whitehead, K. A. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat. Rev. Drug Discov. 20, 817–838 (2021).
Painter, M. M. et al. Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination. Immunity 54, 2133-2142.e3 (2021).
Marshall, J. S., Warrington, R., Watson, W. & Kim, H. L. An introduction to immunology and immunopathology. Allergy Asthma Clin. Immunol. 14, 49 (2018).
Pollard, A. J. & Bijker, E. M. A guide to vaccinology: from basic principles to new developments. Nat. Rev. Immunol. 21, 83–100 (2021).